Dr. Aminuddin Saim

Primary Specialty:

ENT/ Otorhinolaryngology


Malay, English

Staff Attached:

Name : Zalita Abd Aziz

About Dr. Aminuddin Saim

Biological Sketch:
Born in Batu Pahat Johore in 1962. Starts as a consultant and lecturer in PPUKM since 1995 and join KPJ in year 2000. Dr Aminuddin Saim involved in the first cochlear implantation in Malaysia along with Prof Dato Dr Lokman Saim in PPUKM. He is also a pioneer in setting up a pediatric ENT unit in UKM and in stem cell and tissue engineering research along with Prof Dr Ruszymah Idrus since year 2000. He have more then 75 international publications and 12 patents under his name mainly in biomedical research. Dr Aminuddin received many awards for his clinical and research work namely;
1. William P Potsic Award in 2001 for best researcher year 2000 from the North American ENT society.
2. In 2002 Ministry of Science, Technology and the Enviroment of Malaysia Gold Medal Award for the Innovation of Tissue Engineered Trachea.
3. In 2003 Ministry of Science, Technology and the Enviroment of Malaysia Gold Medal Award for the Formation of Tissue Engineered Human Skin For Clinical Application.
4. 2004 Geneva Gold Medal Award For the Innovation of Bioengineered Human skin.
5. 2005 I-TEX Gold Medal Award For The Invention Of Tissue Engineered Bone.

Education and Fellowship:

Education and Fellowship.
Graduated from UKM ( National University of Malaysia) in 1988. Served as a houseofficer and medical officer in Kuantan General Hospital and later transfered to Sarawak General Hospital. In 1990 he join UKM as trainee lecturer and persue his master degree in surgery (ORL) and graduated in 1995. During his masters he was attached to Royal Victorian Eye and Ear Infirmary Hospital Melbourne Australia and conducting study on cochlear implant (bionic ear) for the treatment of hearing loss. In 1998-1999 he continue with his fellowship programme at ENT department Harvard Medical School, Massachussettes Boston and Tissue Engineering Biomedical Research Division of University of Massachussets Worchester USA.

Specialty Interests:

His field of interest:
Rhinology (sinusitis, allergy) , Otology (Hearing loss, Vertigo, Otitis media), Throat diseases and Cancer, Pediatric ENT, Stem cell and tisuue engineering research and clinical aplication. Surgery:
1. Functional endoscopic sinus surgery for sinusitis
2. Balloon sinuplasty and CT scan guided sinus surgery for  sinusitis
3. Pediatric sinusitis and its management
4. Tonsillectomy for tonsillitis
5. Laryngomalacia and tracheal stenosis surgery
6. Ear related diseases with mastoidectomy for chronic ear disease
7. Vocal cord surgery for growth and polyps.
8. Head and neck surgery.

Research and Publications:

Research Publication.
Dr Aminuddin have more then 120 publications among his latest publications:

Shelf Life Evaluation of Clinical Grade Chondrogenic Induced Aged Adult Stem Cells for Cartilage Regeneration. Ude CC, Seet WT, Sharen Aini S, Aminuddin BS, Ruszymah BHI. Sci Rep. 2018 Mar 12;8(1):4345. doi: 10.1038/s41598-018-22748-1.

Long-term evaluation of osteoarthritis sheep knee, treated with TGF-β3 and BMP-6 induced multipotent stem cells.Ude CC, Shamsul BS, Ng MH, Chen HC, Ohnmar H, Amaramalar SN, Rizal AR, Johan A, Norhamdan MY, Azizi M, Aminuddin BS, Ruszymah BHI. Exp Gerontol. 2018 Jan 29;104:43-51. doi: 10.1016/j.exger.2018.01.020

Role of plasma-derived fibrin on keratinocyte and fibroblast wound healing.Law JX, Chowdhury SR, Aminuddin BS, Ruszymah BHI.Cell Tissue Bank. 2017 Dec;18(4):585-595. doi: 10.1007/s10561-017-9645-2. Epub 2017 Jul 26.

Stem cell genes are poorly expressed in chondrocytes from microtic cartilage.Ishak MF, Chua KH, Asma A, Saim L, Aminuddin BS, Ruszymah BH, Goh BS.Int J Pediatr Otorhinolaryngol. 2011 Jun;75(6):835-40.

Formation of tissue engineered composite construct of cartilage and skin using high density polyethylene as inner scaffold in the shape of human helix.Ruszymah BH, Chua KH, Mazlyzam AL, Aminuddin BS.Int J Pediatr Otorhinolaryngol. 2011 Jun;75(6):805-10.
Expansion of human articular chondrocytes and formation of tissue-engineered cartilage: a step towards exploring a potential use of matrix-induced cell therapy.Munirah S, Samsudin OC, Aminuddin BS, Ruszymah BH.Tissue Cell. 2010 Oct;42(5):282-92.
Autologous implantation of bilayered tissue-engineered respiratory epithelium for tracheal mucosal regenesis in a sheep model.Mohd Heikal MY, Aminuddin BS, Jeevanan J, Chen HC, Sharifah SH, Ruszymah BH.Cells Tissues Organs. 2010;192(5):292-302.
Correlation of donor age and telomerase activity with in vitro cell growth and replicative potential for dermal fibroblasts and keratinocytes.Ng MH, Aminuddin BS, Hamizah S, Lynette C, Mazlyzam AL, Ruszymah BH.J Tissue Viability. 2009 Nov;18(4):109-16.

Professional Memberships:

Human serum is an advantageous supplement for human dermal fibroblast expansion: clinical implications for tissue engineering of skin.Mazlyzam AL, Aminuddin BS, Saim L, Ruszymah BH. Arch Med Res. 2008 Nov;39(8):743-52.
Autologous versus pooled human serum for articular chondrocyte growth.Munirah S, Ruszymah BH, Samsudin OC, Badrul AH, Azmi B, Aminuddin BS.J Orthop Surg (Hong Kong). 2008 Aug;16(2):220-9.
Articular cartilage restoration in load-bearing osteochondral defects by implantation of autologous chondrocyte-fibrin constructs: an experimental study in sheep.Munirah S, Samsudin OC, Chen HC, Salmah SH, Aminuddin BS, Ruszymah BH.J Bone Joint Surg Br. 2007 Aug;89(8):1099-109.
Differential osteogenic activity of osteoprogenitor cells on HA and TCP/HA scaffold of tissue engineered bone.Ng AM, Tan KK, Phang MY, Aziyati O, Tan GH, Isa MR, Aminuddin BS, Naseem M, Fauziah O, Ruszymah BH.J Biomed Mater Res A. 2008 May;85(2):301-12.